Cholinomimetic Agents – ANS Pharmacology
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Relative potency of cholinomimetic drugs on the bovine iris sphincter strips.
On the isolated bovine iris sphincter strips, the dose-response curves to several cholinomimetic agents were obtained. When compared at EDS0 the relative potency appears as carbamylcholine 1, furtrethonium 1/5, pilocarpine 1/30, methacholine 1/40, acetylthiocholine 1/1500, acetylcholine 1/4800, and butyrylthiocholine 1/1400. The drugs which are substrate for acetylcholinesterase produce fat dos...
متن کاملEffect of cholinomimetic agents on learning and memory when administered by intra cerebroventricular (ICV) and intraperitonial (ip) routes.
It has been suggested that cholinergic mechanisms are involved in learning and memory (1,4). Since cholino-mimetic drugs appear unique in their ability to alter the above parameters, this study study was undertaken to determine if there was any difference in effects on learning and memory between a directly acting drug drug, viz., pilocarpine and an indirectly acting drug, physostigmnie and als...
متن کاملEffects of cholinomimetic injection into the brain stem reticular formation on halothane anesthesia and antinociception in rats.
The brain stem reticular formation plays an important role in determining consciousness and arousal. Modulation of cholinergic neurotransmission in this region alters the sleep-wake cycle. In the present study, we examined the effect of the direct application of cholinergic agents into the pontine reticular nucleus on anesthetic requirements and recovery and antinociception in rats. Sprague-Daw...
متن کاملSleep induced by drugs injected into the inferior horn of the lateral cerebral ventricle in dogs.
1 In unanaesthetized dogs, cholinomimetic drugs and their antagonists were injected into the inferior horn of the left lateral cerebral ventricle. Injection volumes of 5 mul were used to limit spread of the drugs beyond the inferior horn. The effects on EEG and behaviour were recorded and compared with the effects of the same doses given into the body of the right lateral ventricle a little beh...
متن کاملDrug interaction in psycho-oncology: antidepressants and antineoplastics.
BACKGROUND AND OBJECTIVES Although there is a growing impact of psychiatric and depressive disorders in cancer patients, literature on the idiosyncrasies of antidepressants (ADs) used in those conditions and their interactions with antineoplastic agents (ANs) is scarce. Sharing the same biotransformation pathways enhances the risk of drug interaction between ADs and ANs, specifically when compo...
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تاریخ انتشار 2017